Despite taking the lead in a dominant first-half, a six-minute brace from Sevilla star Coke put pay to Jurgen Klopp’s hopes of silverware in his debut season.
With Basel awash with the red of Liverpool, Klopp’s men made a fine start to the game.
Pressing high and with great intensity, Liverpool were left aggrieved to not get a penalty when Sevilla defender Daniel Carrico seemed to handle inside the box.
Adam Lallana then did well to slip in Daniel Sturridge down the right but the striker couldn’t find a way past Sevilla keeper David Soria.
Despite their good start, Liverpool nearly went behind. Luckily for the Premier League giants, Kevin Gameiro’s spectacular overhead-kick bounced just wide.
Liverpool did then make their early dominance tell. On 34 minutes, Philippe Coutinho fed Sturridge on the edge of the box who bent in a delicious effort with the outside of his boot.
Liverpool thought they had made it 2-0 just four minutes later but Dejan Lovren’s thumping header was ruled out due to Sturridge being in front of Soria and offside.
And the Reds were instantly made to pay for their string of wasted chances just 17 seconds into the second half.
Right from the re-start Sevilla piled forward and Gameiro tapped in from four yards out.
Just after the hour mark the Spaniards took the lead when Coke finished off a scintillating series of one-touch passes by superbly curling past Simon Mignolet.
And Coke then made it 3-1 to Sevilla, smashing in despite major calls for offside.
Sevilla saw the game out impressively to claim their fifth Europa League title and leave Liverpool dejected.